Protection of Allergic Asthma in Mice by Black Rice Bran Bioprocessed with Shiitake Mushroom Mycelia

We evaluated the potential of orally fed new food formulations to inhibit biomarkers reported be involved in causes allergic asthma mice. Asthma, a serious non-communicable disease, affects both adults and children can undertreated. New functional foods could provide therapeutic approaches. Here, anti-asthma mechanism three isolated fractions produced by bioprocessing black rice bran with shiitake mushroom mycelia was mast cells, B mice compared non-bioprocessed bran. In vitro, treatments inhibited RBL-2H3 cell degranulation immunoglobulin E (IgE) production. The vitro effects were confirmed following induction alumina chicken egg ovalbumin (OVA). suppression resulted from inhibition inflammation- immune-related substances, including OVA-specific IgE, thymic stromal lymphopoietin, eotaxin, leukotriene C4, prostaglandin D2, vascular adhesion molecule-1 bronchoalveolar lavage fluid serum. treatment also reversed thickening lung airway wall. inflammation seems regulated balance T-helper cells’ Th1/Th2 immune response multiple associated cause asthma. Future human clinical studies should determine value foods.